Triphasic decline of hepatitis C virus RNA during antiviral therapy

Hepatitis C virus RNA dynamics during antiretroviral therapy.

In a recent issue, Yokozaki et al published a report in which they demonstrated that highly active antiretroviral therapy (HAART) induces a decline in hepatitis C virus (HCV) viremia in hemo-philiac patients with HIV-HCV coinfection. They concluded that coinfected patients should be treated with HAART before starting the treatment with interferon and ribavirin. 1 HIV-HCV coinfection is common a...

The Antiviral Effects of Curcumin Nanomicelles on the Attachment and Entry of Hepatitis C Virus

Background and Aims: Hepatitis C virus (HCV) is a member of the Flaviviridae family, which causes approximately 500,000 deaths annually. HCV infection treatment is often associated with significant adverse effects. Curcumin is an active ingredient of turmeric which has therapeutic anti-inflammatory effects in many diseases including infectious ones. Although curcumin is not soluble in water, if...

Mathematical Models of Hepatitis B Virus Dynamics during Antiviral Therapy

Concise Review Hepatitis C Virus Resistance to Antiviral Therapy

Research produces highly efficient antiviral drugs. At the same time, viruses develop sophisticated strategies to evade their actions. Resistance to antiviral therapy has become a major issue in the management of patients with chronic viral infections. The best known example is human immunodeficiency virus (HIV), but cytomegalovirus, herpes simplex virus, and hepatitis B and C viruses exhibit s...

Antiviral Therapy in Elderly Patients With Hepatitis C Virus Infection.

The emergence of direct-acting antiviral (DAA) agents has revolutionized the treatment schema for hepatitis C virus (HCV) infection. From cure rates to tolerability, DAA agents have shown outstanding profiles compared with the prior therapy of pegylated interferon with ribavirin. However, the efficacy and safety profiles of DAA therapy in older patients, particularly the elderly, have been uncl...